Comments: -A pregnancy exposure registry is available. Animal studies have revealed increased perinatal toxicity and fetotoxicity at doses potentially correlated with maternal toxicity. Some neonates exposed to SNRIs Serotonin and Norepinephrine Reuptake Inhibitors , or SSRIs Selective Serotonin Reuptake Inhibitors late in the third trimester had clinical findings including respiratory distress, cyanosis, apnea, seizures, temperature instability, feeding difficulty, vomiting, hypoglycemia, hypotonia, hypertonia, hyperreflexia, tremor, jitteriness, irritability, and constant crying.
A less than 2-fold increase in postpartum hemorrhage was determined by observational data in patients exposed to the drug within 1 month before birth. A study of women with a history of major depression who were euthymic at the beginning of pregnancy, showed women who discontinued antidepressant medication during pregnancy were more likely to experience a relapse of major depression than women who continued antidepressant medication.
To monitor maternal-fetal outcomes of pregnant women exposed to antidepressant therapy, a National Pregnancy Registry for Antidepressants has been established.
Healthcare providers are encouraged to register patients receiving Cymbalta by calling the Cymbalta Pregnancy Registry at or by visiting www. AU TGA pregnancy category B3: Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals have shown evidence of an increased occurrence of fetal damage, the significance of which is considered uncertain in humans.
Use is not recommended. Comments: -The American Academy of Pediatrics considers this agent a drug for which the effect on nursing infants is unknown but may be of concern. Use is not recommended and a decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.
Comments: -Some experts state that a more thoroughly studied alternative agent e. Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum. Switch to: Professional Interactions. These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Disclaimer: This content should not be considered complete and should not be used in place of a call or visit to a healthcare professional. Medication List Close Cymbalta Xanax. Show 7 interactions. Close all sections. The following applies to the ingredients: Alprazolam found in Xanax Grapefruit and grapefruit juice may interact with ALPRAZolam and lead to potentially dangerous side effects.
The following applies to the ingredients: Duloxetine found in Cymbalta DULoxetine may cause liver damage, and taking it with alcohol may increase that risk. Open all sections. Caffeine acts as a stimulant, increasing the levels of psychological disturbance and opposing the therapeutic effects of the medication. The interaction might also result in hypertension, increased heart rate, and serotonin syndrome. Since treatment with the antidepressant can last for months, many patients develop questions ranging from what to take for headache while on this medication to whether their prescription medications are safe to use with it.
While there are safe drugs to use with duloxetine, there are some that pose health hazards, including worsening withdrawal from Cymbalta. Major drug interactions indicate highly clinically significant effects of combining duloxetine with other medicines. They can lead to severe symptoms, long-lasting damage to health, and even death. Moderate duloxetine interactions signal that it is inadvisable to use Cymbalta with any of the listed medicines.
The effects of duloxetine interactions with the following drugs can be potentially dangerous to health. Duloxetine interactions can range from being mild inconveniences to being potentially life-threatening and severe. It is important to make your medical doctor aware of any medication that you may be on. When taking this drug, it is essential to avoid starting any drugs without making your doctor aware. Having the right information on these drug interactions and avoiding indiscriminate drug use will help avoid adverse health effects.
Since then, Sharon devoted herself entirely to the medical niche. Sharon Levy is also a certified addiction recovery coach. He has a particular interest in psychopharmacology, nutritional psychiatry, and alternative treatment options involving particular vitamins, dietary supplements, and administering auricular acupuncture.
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Last Updated: June 16, Cymbalta and Wellbutrin Coadministration of Cymbalta and Wellbutrin significantly increases the possibility of seizures , particularly in elderly patients and those with a history of a seizure disorder, CNS infections, brain tumors, head traumas, and addiction to opiates or stimulants.
Adderall and Cymbalta The concurrent use of Adderall and Cymbalta can result in increased anxiety, restlessness, and racing thoughts. Xanax and Cymbalta Xanax is the brand name for alprazolam, a benzodiazepine.
Trazodone and Cymbalta When trazodone and Cymbalta are used together, the primary concern is the risk of serotonin syndrome developing. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of duloxetine on the baby.
If you are breastfeeding, tell your doctor if you notice drowsiness, feeding problems, and slow weight gain in the nursing baby. Get emergency medical help if you have signs of an allergic reaction hives, difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling. Report any new or worsening symptoms to your doctor , such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive mentally or physically , more depressed, or have thoughts about suicide or hurting yourself.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.
Use Cymbalta Duloxetine exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Taking duloxetine in higher doses or more often than prescribed will not make it more effective, and may increase side effects. Your symptoms may not improve for up to 4 weeks. You may have unpleasant symptoms if you stop using duloxetine suddenly.
Ask your doctor before stopping the medicine. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Overdose symptoms may include vomiting, dizziness or drowsiness, seizures, fast heartbeats, fainting, or coma.
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